Publications.
research.
Publications.
All of our publications –
compiled in an extensive list:
2025
Signatures of Nonlinear Aging: Molecular Stages of Life: Sudden Changes During Aging as Potential Biomarkers for an Age Classification System.
Olecka M, Morrison H, Hoffmann S (2024) Nonlinear DNA methylation trajectories in aging male mice. Bioessays e202400222.
doi: 10.1002/bies.202400222.
2024
Dietary restriction interventions: lifespan benefits need resilience and are limited by immune compromise and genetics.
Chen Y, Malik A, Rudolph KL (2024) Dietary restriction interventions: lifespan benefits need resilience and are limited by immune compromise and genetics. Signal Transduct Target Ther 9(1):335.
doi: 10.1038/s41392-024-02074-x.
Nonlinear DNA methylation trajectories in aging male mice.
Olecka M, van Bömmel A, Best L, Haase M, Foerste S, Riege K, Dost T, Flor S, Witte OW, Franzenburg S, Groth M, von Eyss B, Kaleta C, Frahm C, Hoffmann S (2024) Nonlinear DNA methylation trajectories in aging male mice. Nat Commun 9;15(1):3074.
doi: 10.1038/s41467-024-47316-2.
Association of dietary patterns with diabetes-related comorbidities varies among diabetes endotypes.
Weber KS, Schlesinger S, Lang A, Straßburger K, Maalmi H, Zhu A, Zaharia OP, Strom A, Bönhof GJ, Goletzke J, Trenkamp S, Wagner R, Buyken AE, Lieb W, Roden M, Herder C; GDS Group (2024) Association of dietary patterns with diabetes-related comorbidities varies among diabetes endotypes. Nutr Metab Cardiovasc Dis. Epub 2024 Jan 5.
doi: 10.1016/j.numecd.2023.12.026.
The levels and trends of cancer incidence in the elderly population at national and sub-national scales in Iran from 1990 to 2016.
Shokri Varniab Z, Saeedi Moghaddam S, Pourabhari Langroudi A, Azadnajafabad S, Mortazavi SS, Sheidaei A, Gohari K, Farzi Y, Shirzad Moghaddam Z, Sohrabi H, Shati M (2024) The levels and trends of cancer incidence in the elderly population at national and sub-national scales in Iran from 1990 to 2016. Cancer Rep (Hoboken). 7(1):e1937.
doi: 10.1002/cnr2.1937.
The burden of ischemic heart disease and its attributable risk factors in North Africa and Middle East, 1990-2019: Results from the GBD study 2019.
Aminorroaya A, Saeedi Moghaddam S, Tavolinejad H, Aryan Z, Heidari B, Ebrahimi H, Naderian M, Shobeiri P, Ghanbari A, Rezaei N, Malekpour MR, Haghshenas R, Rezaei N, Larijani B, Farzadfar F (2024) The burden of ischemic heart disease and its attributable risk factors in North Africa and Middle East, 1990-2019: Results from the GBD study 2019. J Am Heart Assoc 13(2):e030165.
doi: 10.1161/JAHA.123.030165.
Correlates of Skeletal Muscle Mass and Differences Between Novel Subtypes in Recent-onset Diabetes.
Herder C, Maalmi H, Saatmann N, Zaharia OP, Strassburger K, Burkart V, Norman K, Roden M (2024) Correlates of Skeletal Muscle Mass and Differences Between Novel Subtypes in Recent-onset Diabetes. J Clin Endocrinol Metab 109(3):e1238-e1248.
doi: 10.1210/clinem/dgad605.
2023
Does physical fitness affect cognitive functions differently across adulthood? An advantage of being older.
Gajewski PD, Golka K, Hengstler JG, Kadhum T, Digutsch J, Genç E, Wascher E, Getzmann S (2023) Does physical fitness affect cognitive functions differently across adulthood? An advantage of being older. Front Psychol 14, 1134770.
doi: 10.3389/fpsyg.2023.1134770.
A systematic analysis of biological, sociodemographic, psychosocial, and lifestyle factors contributing to the work ability across the working lifespan: a cross-sectional study.
Gajewski PD, Rieker JA, Athanassiou G, Bröde P, Claus M, Golka K, Hengstler JG, Kleinsorge T, Nitsche MA, Reinders J, Tisch A, Watzl C, Wascher E, Getzmann S (2023) A systematic analysis of biological, sociodemographic, psychosocial, and lifestyle factors contributing to the work ability across the working lifespan: a cross-sectional study. JMIR Format Res, 7, e40818.
doi: 10.2196/40818.
Impact of physical fitness, social life, and cognitive functioning on work ability in middle-aged and older adults.
Rieker JA, Gajewski PD, Golka K, Hengstler JG, Wascher E, Reales JM, Ballesteros S, Getzmann S (2023) Impact of physical fitness, social life, and cognitive functioning on work ability in middle-aged and older adults. Int Arch Occup Environ Health 96, 507–520.
doi: 10.1007/s00420-022-01943-8.
Patterns of Dietary Blood Markers Are Related to Frailty Status in the FRAILOMIC Validation Phase.
Henning T, Kochlik B, Ara I, González-Gross M, Fiorillo E, Marongiu M, Cucca F, Rodriguez-Artalejo F, Carnicero Carreño JA, Rodriguez-Mañas L, Grune T, Weber D (2023) Patterns of Dietary Blood Markers Are Related to Frailty Status in the FRAILOMIC Validation Phase. Nutrients 15(5):1142.
doi: 10.3390/nu15051142.
Frailty is characterized by biomarker patterns reflecting inflammation or muscle catabolism in multi-morbid patients.
Kochlik B, Franz K, Henning T, Weber D, Wernitz A, Herpich C, Jannasch F, Aykaç V, Müller-Werdan U, Schulze MB, Grune T, Norman K (2023) Frailty is characterized by biomarker patterns reflecting inflammation or muscle catabolism in multi-morbid patients. J Cachexia Sarcopenia Muscle 14(1), 157-166.
doi: 10.1002/jcsm.13118.
The Link Between Obesity and Aging-Insights Into Cardiac Energy Metabolism
Owesny P, Grune T (2023) The Link Between Obesity and Aging-Insights Into Cardiac Energy Metabolism Mech Ageing Dev 216:111870.
doi: 10.1016/j.mad.2023.111870.
In vitro production of naked mole-rats’ blastocysts from non-breeding females using in vitro maturation and intracytoplasmic sperm injection.
Simone R, Čižmár D, Holtze S, Michel G, Sporbert A, Okolo C, Hildebrandt TB (2023) In vitro production of naked mole-rats’ blastocysts from non-breeding females using in vitro maturation and intracytoplasmic sperm injection. Sci Rep 13(1):22355.
doi: 10.1038/s41598-023-49661-6.
Macrophages from naked mole-rat possess distinct immunometabolic signatures upon polarization.
Gorshkova EA, Gubernatorova EO, Dvorianinova EM, Yurakova TR, Marey MV, Averina OA., Holtze S, Hildebrandt TB, Dmitriev AA, Drutskaya MS, Vyssokikh MY, Nedospasov SA (2023) Macrophages from naked mole-rat possess distinct immunometabolic signatures upon polarization. Front Immunol 14, 1172467.
doi: 10.3389/fimmu.2023.1172467.
Comparative analysis of thyroid hormone systems in rodents with subterranean lifestyle.
Gerhardt P, Begall S, Frädrich C, Renko K, Hildebrandt TB, Holtze S, Heinrich A, Sahm A, Xheni M, Köhrle J, Rijntjes E, Henning Y (2023) Comparative analysis of thyroid hormone systems in rodents with subterranean lifestyle. Sci Rep 13, 3122.
doi: 10.1038/s41598-023-30179-w.
Which Factors Influence Early Pup Survival in Naked Mole-Rats?
Wetzel M, Courtiol A, Hofer H, Holtze S, Hildebrandt TB (2023) Pup Recruitment in a Eusocial Mammal—Which Factors Influence Early Pup Survival in Naked Mole-Rats? Animals 13, 630.
doi: 10.3390/ani13040630.
Serum neurofilament light chain: a novel biomarker for early diabetic sensorimotor polyneuropathy.
Maalmi H, Strom A, Petrera A, Hauck SM, Strassburger K, Kuss O, Zaharia OP, Bönhof GJ, Rathmann W, Trenkamp S, Burkart V, Szendroedi J, Ziegler D, Roden M, Herder C; GDS Group (2023) Serum neurofilament light chain: a novel biomarker for early diabetic sensorimotor polyneuropathy. Diabetologia 66(3):579-589.
doi: 10.1007/s00125-022-05846-8.
Neuropathy in prediabetes.
Ziegler D, Herder C, Papanas N (2023) Neuropathy in prediabetes. Diabetes Metab Res Rev 39(8):e3693.
doi: 10.1002/dmrr.3693.
Diabetes and climate change: current evidence and implications for people with diabetes, clinicians and policy stakeholders.
Ratter-Rieck JM, Roden M, Herder C (2023) Diabetes and climate change: current evidence and implications for people with diabetes, clinicians and policy stakeholders. Diabetologia 66(6):1003-1015.
doi: 10.1007/s00125-023-05901-y.
Environmental risk factors of incident distal sensorimotor polyneuropathy: Results from the prospective population-based KORA F4/FF4 study.
Herder C, Zhang S, Wolf K, Maalmi H, Bönhof GJ, Rathmann W, Schwettmann L, Thorand B, Roden M, Schneider A, Ziegler D, Peters A (2023) Environmental risk factors of incident distal sensorimotor polyneuropathy: Results from the prospective population-based KORA F4/FF4 study. Sci Total Environ 858(Pt 3):159878.
doi: 10.1016/j.scitotenv.2022.159878.
Effects of Short- And Medium-Term Exposures to Lower Air Temperature on 71 Novel Biomarkers of Subclinical Inflammation: Results from the KORA F4 Study
Ni W, Breitner S, Nikolaou N, Wolf K, Zhang S, Peters A, Herder C, Schneider A. Effects of Short- And Medium-Term Exposures to Lower Air Temperature on 71 Novel Biomarkers of Subclinical Inflammation: Results from the KORA F4 Study (2023) Environ Sci Technol 57(33):12210-12221.
doi: 10.1021/acs.est.3c00302.
Comparison of Frailty and Chronological Age as Determinants of the Murine Gut Microbiota in an Alzheimer’s Disease Mouse Model.
Kapphan LM, Nguyen VTT, Heinrich I, Tüscher O, Passauer P, Schwiertz A, Endres K (2023) Comparison of Frailty and Chronological Age as Determinants of the Murine Gut Microbiota in an Alzheimer’s Disease Mouse Model. Microorganisms. 11(12):2856.
doi: 10.3390/microorganisms11122856.
The relationship between interhemispheric transfer time and physical activity as well as cardiorespiratory fitness in healthy older adults.
Riedel D, Lorke N, Mierau A, Strüder HK, Wolf D, Fischer F, Fellgiebel A, Tüscher O, Kollmann B, Knaepen K (2023) The relationship between interhemispheric transfer time and physical activity as well as cardiorespiratory fitness in healthy older adults. Exp Gerontol. 176:112167.
doi: 10.1016/j.exger.2023.112167.
The Aging Enteric Nervous System.
Nguyen TT, Baumann P, Tüscher O, Schick S, Endres K (2023) The Aging Enteric Nervous System. Int J Mol Sci. 24(11):9471.
doi: 10.3390/ijms24119471.
Diagnostic testing for hypertension, diabetes, and hypercholesterolaemia in low-income and middle-income countries: a cross-sectional study of data for 994185 individuals from 57 nationally representative surveys.
Ochmann S, von Polenz I, Marcus ME, Theilmann M, Flood D, Agoudavi K, Aryal KK, Bahendeka S, Bicaba B, Bovet P, Campos Caldeira Brant L, Carvalho Malta D, Damasceno A, Farzadfar F, Gathecha G, Ghanbari A, Gurung M, Guwatudde D, Houehanou C, Houinato D, Hwalla N, Jorgensen JA, Karki KB, Lunet N, Martins J, Mayige M, Moghaddam SS, Mwalim O, Mwangi KJ, Norov B, Quesnel-Crooks S, Rezaei N, Sibai AM, Sturua L, Tsabedze L, Wong-McClure R, Davies J, Geldsetzer P, Bärnighausen T, Atun R, Manne-Goehler J, Vollmer S (2023) Diagnostic testing for hypertension, diabetes, and hypercholesterolaemia in low-income and middle-income countries: a cross-sectional study of data for 994185 individuals from 57 nationally representative surveys. Lancet Glob Health 11(9):e1363-e1371.
doi: 10.1016/S2214-109X(23)00280-2.
Diabetes risk and provision of diabetes prevention activities in 44 low-income and middle-income countries: a cross-sectional analysis of nationally representative, individual-level survey data.
Rahim NE, Flood D, Marcus ME, Theilmann M, Aung TN, Agoudavi K, Aryal KK, Bahendeka S, Bicaba B, Bovet P, Diallo AO, Farzadfar F, Guwatudde D, Houehanou C, Houinato D, Hwalla N, Jorgensen J, Kagaruki GB, Mayige M, Wong-McClure R, Larijani B, Saeedi Moghaddam S, Mwalim O, Mwangi KJ, Sarkar S, Sibai AM, Sturua L, Wesseh C, Geldsetzer P, Atun R, Vollmer S, Bärnighausen T, Davies J, Ali MK, Seiglie JA, Manne-Goehler J (2023) Diabetes risk and provision of diabetes prevention activities in 44 low-income and middle-income countries: a cross-sectional analysis of nationally representative, individual-level survey data. Lancet Glob Health 11(10):e1576-e1586.
doi: 10.1016/S2214-109X(23)00348-0.
Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021.
GBD 2021 Diabetes Collaborators (2023) Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet 402(10397):203-234.
doi: 10.1016/S0140-6736(23)01301-6.
Digital Technologies for Health Promotion and Disease Prevention in Older People: Scoping Review.
De Santis KK, Mergenthal L, Christianson L, Busskamp A, Vonstein C, Zeeb H (2023) Digital Technologies for Health Promotion and Disease Prevention in Older People: Scoping Review. J Med Internet Res 25:e43542.
doi: 10.2196/43542.
Determinants and indicators of successful aging as a multidimensional outcome: a systematic review of longitudinal studies.
Rodrigues CE, Grandt CL, Alwafa RA, Badrasawi M, Aleksandrova K (2023) Determinants and indicators of successful aging as a multidimensional outcome: a systematic review of longitudinal studies. Front Public Health 11:1258280.
doi: 10.3389/fpubh.2023.1258280.
Adherence to Healthy and Sustainable Dietary Patterns and Long-Term Chronic Inflammation: Data from the EPIC-Potsdam Cohort.
Koelman L, Herpich C, Norman K, Jannasch F, Börnhorst C, Schulze M, Aleksandrova K (2023) Adherence to Healthy and Sustainable Dietary Patterns and Long-Term Chronic Inflammation: Data from the EPIC-Potsdam Cohort. J Nutr Health Aging 27(11):1109-1117.
doi: 10.1007/s12603-023-2010-1.
Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer.
Nimptsch K, Aleksandrova K, Pham TT, Papadimitriou N, Janke J, Christakoudi S, Heath A, Olsen A, Tjønneland A, Schulze MB, Katzke V, Kaaks R, van Guelpen B, Harbs J, Palli D, Macciotta A, Pasanisi F, Yohar SMC, Guevara M, Amiano P, Grioni S, Jakszyn PG, Figueiredo JC, Samadder NJ, Li CI, Moreno V, Potter JD, Schoen RE, Um CY, Weiderpass E, Jenab M, Gunter MJ, Pischon T (2023) Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer. BMC Med 21(1):391. doi: 10.1186/s12916-023-03104-1.
Genetically determined circulating resistin concentrations and risk of colorectal cancer: a two-sample Mendelian randomization study.
Pham TT, Nimptsch K, Papadimitriou N, Aleksandrova K, Jenab M, Gunter MJ, Le Marchand L, Li L, Lynch BM, Castellví-Bel S, Phipps AI, Schmit SL, Brenner H, Ogino S, Giovannucci E, Pischon T (2023) Genetically determined circulating resistin concentrations and risk of colorectal cancer: a two-sample Mendelian randomization study. J Cancer Res Clin Oncol 149(16):14889-14900.
doi: 10.1007/s00432-023-05193-0.
Proteomic analysis of peripheral nerve myelin during murine aging.
Helbing DL, Kirkpatrick JM, Reuter M, Bischoff J, Stockdale A, Carlstedt A, Cirri E, Bauer R, Morrison H (2023) Proteomic analysis of peripheral nerve myelin during murine aging. Front Cell Neurosci 17:1214003.
doi: 10.3389/fncel.2023.1214003.
Comparative analysis of thyroid hormone systems in rodents with subterranean lifestyle.
Gerhardt P, Begall S, Frädrich C, Renko K, Hildebrandt TB, Holtze S, Heinrich A, Sahm A, Meci X, Köhrle J, Rijntjes E, Henning Y (2023) Comparative analysis of thyroid hormone systems in rodents with subterranean lifestyle. Sci Rep 13(1):3122.
doi: 10.1038/s41598-023-30179-w.
Evolution, mechanism and limits of dietary restriction induced health benefits & longevity.
Becker F, Behrends MM, Rudolph KL (2023) Evolution, mechanism and limits of dietary restriction induced health benefits & longevity. Redox Biol 63:102725.
doi: 10.1016/j.redox.2023.102725.
2022
Dietary Inflammatory Index and Cross-Sectional Associations with Inflammation, Muscle Mass and Function in Healthy Old Adults.
Haß U, Herpich C, Kochlik B, Weber D, Grune T, Norman K (2022) Dietary Inflammatory Index and Cross-Sectional Associations with Inflammation, Muscle Mass and Function in Healthy Old Adults. J Nutr Health Aging 26, 346–351.
doi: 10.1007/s12603-022-1753-4.
Fasting concentrations and postprandial response of 1,2-dicarbonyl compounds 3-deoxyglucosone, glyoxal and methylglyoxal are not increased in healthy older adults.
Herpich C, Kochlik B, Weber D, Ott C, Grune T, Norman K, Raupbach J (2022) Fasting concentrations and postprandial response of 1,2-dicarbonyl compounds 3-deoxyglucosone, glyoxal and methylglyoxal are not increased in healthy older adults. J Gerontol Ser A-Biol Sci Med Sci 77(5), 934–940. doi: 10.1093/gerona/glab331.
Methionine restriction – Association with redox homeostasis and implications on aging and diseases.
Zhang Y, Jelleschitz J, Grune T, Chen W, Zhao Y, Jia M, Wang Y, Liu Z, Höhn A (2022) Methionine restriction – Association with redox homeostasis and implications on aging and diseases. Redox Biol 57:102464. doi: 10.1016/j.redox.2022.102464.
Editorial: Recent advances in the ecology and evolution of the Bathyergidae.
Braude S, Holtze S, Bennett NC, Begall S (2022) Editorial: Recent advances in the ecology and evolution of the Bathyergidae. Front Ecol Evol 10:1017185.
doi: 10.3389/fevo.2022.1017185.
Unique features of the tissue structure in the naked mole rat (Heterocephalus glaber): hypertrophy of the endoplasmic reticulum and spatial mitochondrial rearrangements in hepatocytes.
Vays V, Vangely I, Eldarov C, Popkov V, Holtze S, Hildebrandt T, Averina OA, Bakeeva L, Zorov D (2022) Unique features of the tissue structure in the naked mole rat (Heterocephalus glaber): hypertrophy of the endoplasmic reticulum and spatial mitochondrial rearrangements in hepatocytes. Int J Mol Sci 23 9067, 1-15.
doi: 10.3390/ijms23169067.
The mating pattern of captive naked mole-rats is best described by a monogamy model.
Szafranski K, Wetzel M, Holtze S, Büntjen I, Lieckfeldt D, Ludwig A, Huse K, Platzer M, Hildebrandt TB (2022) The mating pattern of captive naked mole-rats is best described by a monogamy model. Front Ecol Evol 10, 1-9.
doi: 10.3389/fevo.2022.855688.
Chronic air pollution-induced subclinical airway inflammation and polygenic susceptibility.
Kress S, Wigmann C, Zhao Q, Herder C, Abramson MJ, Schwender H, Schikowski T (2022) Chronic air pollution-induced subclinical airway inflammation and polygenic susceptibility. Respir Res 23(1):265.
doi: 10.1186/s12931-022-02179-3.
The impact of aging on interhemispheric transfer time and respective sex differences. Aging Brain.
Riedel D, Fellerhoff T, Mierau A, Strüder H, Wolf D, Fischer F, Fellgiebel A, Tüscher O, Kollmann B, Knaepen K (2022) The impact of aging on interhemispheric transfer time and respective sex differences. Aging Brain. 2:100040.
doi: 10.1016/j.nbas.2022.100040.
Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations.
Nimptsch K, Aleksandrova K, Fedirko V, Jenab M, Gunter MJ, Siersema PD, Wu K, Katzke V, Kaaks R, Panico S, Palli D, May AM, Sieri S, Bueno-de-Mesquita B, Standahl K, Sánchez MJ, Perez-Cornago A, Olsen A, Tjønneland A, Bonet CB, Dahm CC, Chirlaque MD, Fiano V, Tumino R, Gurrea AB, Boutron-Ruault MC, Menegaux F, Severi G, van Guelpen B, Lee YA, Pischon T (2022) Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations. BMC Cancer 22(1):695.
doi: 10.1186/s12885-022-09778-9.
The role of exosomes in intercellular and inter-organ communication of the peripheral nervous system.
Bischoff JP, Schulz A, Morrison H (2022) The role of exosomes in intercellular and inter-organ communication of the peripheral nervous system. FEBS Lett 596(5):655-664.
doi: 10.1002/1873-3468.14274.
Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction.
Rasa SMM, Annunziata F, Krepelova A, Nunna S, Omrani O, Gebert N, Adam L, Käppel S, Höhn S, Donati G, Jurkowski TP, Rudolph KL, Ori A, Neri F (2022) Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction. Cell Rep 39(13):111017.
doi: 10.1016/j.celrep.2022.111017.
